Microbial Collagenase FDA Link

A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.

Also Known As:

Clostridiopeptidase A; Clostridium histolyticum Collagenase; Collagenase Clostridium histolyticum; Collagenase-Like Peptidase; Collalysine; Nucleolysin; Clostridium histolyticum, Collagenase; Collagenase Like Peptidase; Collagenase, Clostridium histolyticum; Peptidase, Collagenase-Like; histolyticum, Collagenase Clostridium; Collagenase, Microbial

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Metalloproteases: 8398
        Metalloendopeptidases: 70
        Collagenases: 4042
        Microbial Collagenase: 372
      - Endopeptidases: 643
        Metalloendopeptidases: 70
        Collagenases: 4042
        Microbial Collagenase: 372

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Disease

Drug/Important Bio-Agent (IBA)